Exhibit 10.58

                                                       PERSONAL AND CONFIDENTIAL

                                   May 3, 2000

Mr. James C. Mullen
138 Richardson Drive
Needham, MA 02492

Dear Jim:

As a follow-up to our conversation last Friday, I am pleased to confirm that the
Board of Directors has approved your appointment as President and Chief
Executive Officer of Biogen, Inc., effective June 16, 2000.

Concurrent with the effective date of your appointment, the Board of Directors
has also approved an adjustment in your annual base salary to $700,000, and has
established a target of 90% of your base salary for your cash bonus in 2000. In
addition, you will be granted an option to purchase 250,000 shares of Biogen
Common Stock, effective June 16, 2000, with a seven-year, straight-line vesting

Jim, on behalf of the other members of the Board, I wish you the best of success
as you take over the leadership of Biogen next month.

In the interim, please let me know how I can assist you in the transition to
your new role.


                                            /s/ James L. Vincent
                                            James L. Vincent
                                            Chairman and Chief Executive Officer